In 1932 the Epsilon Chapter at The Ohio State University School of Nursing was the fourth chapter to be chartered by Sigma Theta Tau, the international honor society of nursing. The charter members included nine nursing students and two faculty members.

The focus of the Epsilon Chapter is educational excellence and research as well as service to nursing and society.

In 1939, the Epsilon Chapter was the first chapter to initiate post-graduate students who were registered nurses who had returned to school to earn a baccalaureate degree.

The next forty years of the Epsilon Chapter were involved with promotion of scholarship, recruitment of members, and service. In 2007 the Epsilon Chapter celebrated its 70th anniversary. Over 2800 members have been inducted into the Epsilon Chapter.