The Holmes Partnership Records contains bylaws and other records about the establishment of the Holmes Group and its eventual change to become the Holmes Partnership, regional office files, records related to institution membership in the organisation, committees, the Executive Board and Board of Directors, grant proposals, studies, the organisation's annual meeting, and seminars. Materials are dated 1985-1997.

The collection consists of original art, in a variety of media, and includes tearsheets, proofs, posters, mechanicals and photographs of Eisner's works; general papers; business correspondence; fan mail; educational materials developed by Eisner, such as the series Grammarfun; comic books; examples of his commercial products; books illustrated by Eisner; scrapbooks; magazine articles by or about Will Eisner; merchandise, mostly from The Spirit; memorabilia. Also included are works by artists who worked for Eisner, such as Jules Feiffer, Andre LeBlanc, Klaus Nordling and Fred Schwab. Numerous works by Eisner, including PS, are cataloged separately in the library catalog.