This collection contains original art and photocopied comics pages and illustrations by Stan Goldberg, as well as the artist's handwritten notes and copies of personal photographs. Correspondence relating to Mr. Goldberg's philanthropic work and from notable people such as Charles Schulz, Mort Walker, Jim Davis, and Stan Lee are housed in the collection's correspondence series. The original artwork series has been separated and is cataloged by the item level in the Billy Ireland Cartoon Library & Museum Art Database.

The collection consists of original art, in a variety of media, and includes tearsheets, proofs, posters, mechanicals and photographs of Eisner's works; general papers; business correspondence; fan mail; educational materials developed by Eisner, such as the series Grammarfun; comic books; examples of his commercial products; books illustrated by Eisner; scrapbooks; magazine articles by or about Will Eisner; merchandise, mostly from The Spirit; memorabilia. Also included are works by artists who worked for Eisner, such as Jules Feiffer, Andre LeBlanc, Klaus Nordling and Fred Schwab. Numerous works by Eisner, including PS, are cataloged separately in the library catalog.