Upham Hall was built in 1951. It was a reinforced concrete frame with brick exterior.  It consisted of a basement with four floors and a penthouse. The building had two additions. It was located where the OSU Harding Hospital and the Davis Heart and Lung Research Institute now stand on 12th ave. Upham Hall was used for psychiatric care. It was demolished in 1998.

John Howell Janeway Upham (1871-1960) received his BS (1891) and MD (1894) from the University of Pennsylvania. He was a professor at Starling Medical College (1897-1899), Ohio Medical University (1900-1902), Starling-Ohio Medical College (1907-1914), and Ohio State (1914-1941). He served as Dean of the OSU College of Medicine from 1928-1941.